Molecular Markers and Death From Prostate Cancer

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Molecular markers and death from prostate cancer.

BACKGROUND Current methods to assess the prognosis of prostate cancer at the time of diagnosis are limited. OBJECTIVE To determine whether molecular markers of cell cycle regulation (bcl-2 and p53) and angiogenesis (beta-3 integrin, vascular endothelial growth factor, and microvessel density) are associated with increased long-term risk for death among men with prostate cancer. DESIGN Obser...

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Prostate cancer is a highly prevalent malignancy, which is clinically silent but curable while organ-confined. Because available screening methods show poor sensitivity and specificity, the development of new molecular markers is warranted. Epigenetic alterations, mainly promoter hypermethylation of cancer-related genes, are common events in prostate cancer and might be used as cancer biomarker...

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Assessing the lethality of 'early,' potentially organ-confined prostate cancer (PCa) is one of the central controversies in modern-day urological clinical practice. Such cases are often considered for radical 'curative' treatment, although active surveillance may be equally appropriate for many men. Moreover, the balance between judicious intervention and overtreatment can be difficult to judge...

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ژورنال

عنوان ژورنال: Annals of Internal Medicine

سال: 2009

ISSN: 0003-4819

DOI: 10.7326/0003-4819-150-9-200905050-00005